| Certification: | ISO |
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| Assay Method: | HPLC |
| Application Form: | Lotion, Suppository, Paste, Tablet, Capsule |
| Application: | Food, Health Care Products, Medicine, Skin Care Product |
| State: | Powder |
| Extract Source: | Magnolia Officinalis Bark Extract |
| Samples: |
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| Customization: |
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Suppliers with verified business licenses
Audited Supplier | Product Name | CAS Number | INCI Name | |
| Honokiol | 35354-74-6 | Honokiol | |
| Molecular Formula | Molecular Weight | Specificcation | |
| C18H18O2 | 266.33g/mol | 98% | |
Honokiol is a polyphenol compound. It naturally exists in dry bark and root of magnolia officinalis. Honokiol and its isomer Magnolol both are present in Chinese medicine magnolia officinalis.
It not only has a variety of pharmacological activities, but also has good bioactivities for skin care. Honokiol can improve immune ability of skin cells, and has anti-inflammatory effect. Also Honokiol has a broad antibacterial spectrum. It can resist acid bacteria, and also exhibit inhibitory effect on gram-negative bacteria. Thus Honokiol can be used in prevention and treatment of acne.
In addition, Honokiol plays an important role in anti-caries and inhibiting tooth decay in oral hygiene products. Honokiol is found to have activity as an antioxidant and skin whitening agent. At present, as a new natural cosmetic raw material, Honokiol is widely applied in anti-acne, whitening and anti-oxidation skin care products.
In addition to Honokiol, we also supply Magnolol 98%, and No solvent residue magnolol + honokiol 98%
Honokiol has a broad anti-bacterial spectrum. Its antibacterial property is stable, and it's not easy to be damaged by heat, acid, alkali. Some scholars have found that Honokiol has a strong inhibitory effect on streptococcus mutans. The result shows that it has good antibacterial effect on staphylococcus aureus; and its MIC is 6.25μg/mL. Therefore, Honokiol can be added into cosmetics to treat acne, and can also be used as a natural preservative of cosmetics.
2-Anti-acne and anti-inflammationHonokiol has strong inhibitory effect on P.acnes and P.granulosum that can lead to acne. The MIC is 9mg/L. Furthermore, it can effectively reduce the increase of THP-1cell, IL-8 and TNF-αcaused by P.acnes. So it proves that Honokiol can treat local skin inflammation.
3-Anti-aging and whiteningStudy has shown that Honokiol can enhance activity of antioxidant enzymes such as SOD, CAT and GSH2Px in serum and tissues of mice; and it can lower the content of MDA, a lipid peroxide in the body. Under the action of Honokiol, antioxidant capacity of human body has been improved. And excessive free radicals produced by aging body can be quickly eliminated. Thereby, further chain reaction of oxygen free radical is blocked, and per-oxidation process of tissues and cells is inhibited. Thus Honokiol can exert its anti-aging effect. Moreover, the scavenging capacity of Honokiol on free radicals is stronger than that of classic antioxidant ascorbic acid. And Honokiol can also inhibit tyrosinase activity; so it has certain whitening function, and can be used in cosmetics as skin whitening agent.
Pharmacological studies of Honokiol and cosmetics
| Test Item | Concentration | Result |
| Elimination to hydroxyl radicals | 0.2mmol/L | Elimination rate: 82.5% |
| Elimination to free radical DPPH | 50μmol/L | Elimination rate: 23.6% |
| Inhibition to unsaturated fatty acid peroxidation | 0.2mmol/L | Inhibition rate: 85.8% |
| Inhibition to tyrosinase activity | 0.01% | Inhibition rate: 38.8% |
| Inhibition to NF-kB cell activity | 20μmol/L | Inhibition rate: 20.4% |
| Inhibition to metalloproteinase MMP-1 activity | 10μmol/L | Inhibition rate: 18.2% |
Honokiol is widely used in cosmetics and other daily chemicals:
1-Dental products (toothpaste, mouth wash) for prevention of gingivitis; recommended dosage is 0.3%. As a natural preservative in cosmetics.
Honokiol application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| Switzerland | L'ADMIRER | Beauty Plus Defensil Concentrate |
| SURPUR | Radiant Day Cream | |
| Thailand | VLanse | Milk Bath Cream
Q10 Skin Refining and Whitening Scrub Q10 Facial Foam |
| German | NIVEA | Cell Ular Anti-Age Eye Cream |
| France | Sa[è]ve | Firming and Repairing Essence
Moisturizing Emulsion Moisturizing Day Cream Firming and Repairing Night Cream |
| UAS | Richme | Day Facial Cream |
| Estee Lauder | Re-nutriv Ultimate Diamond Transformative Energy Eye Cream |
1-Cosmetic, Toiletry & Fragrance Association (CTFA) has specified Honokiol as a cosmetics ingredient.
2-Honokiol is listed on The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014. No reports show its insecurity.Certificate of Analysis (Hongkangbio-Honokiol)
| Product Name | Specification | |
| Honokiol | 98% HPLC | |
| Items | Specification | |
| Assay | ≥98.00% | |
| Color | White fine powder | |
| Odor | Characteristic | |
| Taste | Characteristic | |
| Extract Solvent | Water & ethanol | |
| Part used | Bark | |
| Physical Characteristics | ||
| Particle Size | 98% through 80 mesh | |
| Moisture | ≤1.00% | |
| Ash content | ≤1.00% | |
| Bulk density | 50-60g/100ml | |
| Solvent Residue | Eur. Pharm | |
| Heavy Metals | ||
| Heavy metals | ≤10ppm | |
| Arsenic | ≤2ppm | |
| Plumbum | ≤2ppm | |
| Microbiological Tests | ||
| Total Plate count | ≤1000cfu/g | |
| Yeast & mold | ≤100cfu/g | |
| Escherichia coli | Negative | |
| Staphylococcus | Negative | |
| Salmonella | Negative | |
Shipping:
| Recommended transportation selections | ||
| By Express | By Air Transportation | By Sea Transportation |
| Suitable for sample order or <50kg Fast: 3-10 days High shipping cost Door to door service |
Suitable for >50kg Fast: 3-7 days Lower than express cost Airport to airport service Professional broker needed |
Suitable for > 300kg Slow: 7-45 days Lowest cost Port to port service Professional broker needed |
Shaanxi Hongkang Biological Technology Co., Ltd was founded in 2010, professional committed to the natural plant active ingredient research, development, production and sales, with own import and export rights. Widely used in cosmetics, health products, food additives and other industries. Shaanxi Hongkang will continuously to focus on and serve human health from a global perspective, and create high-quality products in the field of green health.
After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network.Company has perfect quality assurance system, implement strict quality control standards.
The quality management department is equipped with a number of sets of UV, GC,HPLC, GC-MS and other advanced testing and experimental instruments.Besides, it has a detailed division of labor for the three functions of process research, quality assurance and quality inspection, which can effectively and comprehensively control the quality of the production process, conduct comprehensive inspection and analysis on the final product, and ensure the quality of the product.
1-More than 11 years of experince in the Industry of "plant extract"!
Shaanxi Hongkang Biological Technology Co., Ltd. (HONGKANGBIO)has been dedicated to the research and1. Can I get some free products for testing?
Sure, If you have a need for this,we can provide free samples after you pay for shipping.
2. What is the meaning of the minimum order quantity?
We have different minimum order metrics for different products, usually 1KG
3. How much time can your send the goods?
Usually 3-5 days,except statutory holidays
4. Is there any discount?
Of course, the price will vary with the quantity, the more you buy, the more discounts you have.
5. How do you deal with quality complaints?
We are striving to keep quality issues close to zero,If quality problems have occurred,we will make a consistent
replacement or refund for customers who have quality problems.
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Audited Supplier 
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