Common Cnidium Extract Osthole 10%-98% by HPLC

• Customization: Available
• Certification: RoHS, BRC, ISO, FDA, HACCP
• Assay Method: HPLC
• Model NO.: Osthole
• Application Form: Injection, Lotion, Suppository, Paste, Tablet, Capsule
• Application: Food, Health Care Products, Medicine, Health-Care Products, Cosmetic Products
• State: Powder
• Extract Source: Cnidium Monnieri Extract
• Product Name: Osthole
• Other Name: Osthol, Cnidium
• CAS No: 484-12-8
• Mf: C15h16o3
• Extraction Type: Solvent Extraction
• Part Used: Seed
• Grade: Food Grade, Medical Grade
• Function: Itching, Sterilization, Aphrodisiac
• MOQ: 10g
• Sample: Support
• Storage Conditions: Store in a Dry and Dark Place, Sealed
• Shelf Life: 2 Years
• Transport Package: 1.1 Kg Aluminum Foil Bag; 2.10 Kg Carton Packing
• Specification: 50%
• Trademark: HONGKANGBIO
• Origin: China
• HS Code: 2938909090
• Production Capacity: 10000kg/M

Product Description

Common Cnidium Extract Osthole 10%-98% by HPLC

Product Name	Cnidium monnieri Extract Osthole
Exterior	White, light yellow, brownish yellow powder
Active Ingredient	Osthole 10%, 30%, 50%, 90%, 98%
Test Method	HPLC
Extraction Solvent	Ethanol
CAS NO	482-12-8
Molecular Formula	C15H16O3
Molecular Weight	244.29

Osthol, also known as methoxyparsley, parsley methyl ether, is a coumarin compounds, in the umbrella
plant osthol content is high,so called osthol. In 1909, Herzog and Krohn first obtained the compound osthol
from the roots of the umbrella plant europhus. At present, it is widely found in plants, mainly in umbelliferae
and rutaceae, and also in a few compositae and legumes. Commercial cnidium cnidium is mainly extracted
from dried and ripe fruit of cnidium cnidium. Cnidium is mainly distributed in guangxi, jiangsu, anhui, shandong,
hebei, etc. Because of its various biological activities, cnidium is widely used in cosmetics, medicine and
agriculture.

We have 98% ,90% ,50%,30%,10% Osthol,that can meets defferent requirement.

 

1-Function:

Antiarrhythmic effect
        Water extract and total coumadin from fructus cnidium have obvious preventive effects on chloroform
induced ventricular fibrillation in mice and calcium chloride induced ventricular fibrillation in rats. Fructus
cnidium and zanthoxylum acetaminophen also have this pharmacological effect and can improve ventricular
electrofibrillation threshold in rabbits. The water extract, total coumarin, cnidium, and phenols of zanthoxylum
had significant inhibitory effects on the flow of sodium ions in the myocardial cell membrane.
 
Antihypertensive, inhibition of vascular dilatation
      Osthol had a dose-dependent negative inotropic effect on the left atrium of isolated guinea pigs and a
negative frequency effect on the left atrium of isolated guinea pigs. In addition to the polarization induced by
norepinephrine, CaCl2 and high K+, the aorta contraction dose-response curve of rabbits was shifted to the
right and the maximum response was decreased, indicating the role of biosynthetic compound in relaxing
vascular smooth muscle. Fructus cnidium has a certain antihypertensive effect.

Effects on respiratory system
      Cnidium monnieri total coumarin with relaxation by drugs (histamine and acetylcholine) caused by bronchial
spasms and diastole bronchus role directly, this function can be B - adrenaline receptor blockers block by propranolol,
mice after total coumarin cnidium monnieri, obviously increase the amount of phenol red drain in the body, shows
strong expectoranting action.

Anti-inflammatory effects
      Cnidium cnidium and phenolic zanthoxylum could inhibit the ear shell swelling of mice caused by xylene
and the increase of capillary permeability in abdominal cavity caused by acetic acid. Osthol and acetonol had
significant inhibitory effects on foot swelling in rats and rats with bilateral adrenal resection. Osthol could also
reduce the PGE content in the inflammatory tissues of the swollen part of the foot in rats, but osthol did not
affect the PGE content in the inflammatory tissues of the swollen part of the foot in rats.

Effects on the nervous system
      The total coumarin of cnidium cnidium has an inhibitory effect on central nervous system. Osthol can
significantly enhance the hypnotic effect of pentobarbital sodium on subthreshold hypnotic dose in mice, and
this hypnotic effect is dose-related. Cnidium cnidium can promote the learning and memory of mice, and
significantly improve the memory acquisition, consolidation and direction discrimination of mice.

Anti - mutagenesis, anti - cancer effect
      Cnidium, parsley b, bergamot lactone, isorhein, zanthoxylum acetaminophen and zanthoxylum toxin
have high activity in inhibiting the mutagenesis of aflatoxin B1. Water extract of cnidium could inhibit S130
sarcoma, prolong survival days and inhibit tumor growth.

2-Application

Skin care products and cosmetics

      It can inhibit the formation of various inflammatory factors and has a good therapeutic effect on facial
acne and acne.For allergic skin diseases, such as eczema, urticaria has a good effect, can be used in anti-
allergic cosmetics.
 

Dermatological drugs

      Osthole has antispasmodic, antihypertensive, antiarrhythmic, immune function and broad-spectrum
antibacterial effects. It has strong pharmacological activity and is an effective pharmaceutical ingredient
that can be used in the pharmaceutical industry.
 

Pesticides and pesticides

      As a new type of biological pesticide, it can inhibit pests and plant pathogens. It is an effective botanical
insecticide.



COA:

Items	Standards	Results
Physical Analysis
Description	White Powder	Complies
Assay	98%	98.2%
Mesh Size	100 % pass 80 mesh	Complies
Ash	≤ 5.0%	2.85%
Loss on Drying	≤ 5.0%	2.85%
Chemical Analysis
Heavy Metal	≤ 10.0 mg/kg	Complies
Pb	≤ 2.0 mg/kg	Complies
As	≤ 1.0 mg/kg	Complies
Hg	≤ 0.1 mg/kg	Complies
Microbiological Analysis
Residue of Pesticide	Negative	Negative
Total Plate Count	≤ 1000cfu/g	Complies
Yeast&Mold	≤ 100cfu/g	Complies
E.coil	Negative	Negative
Salmonella	Negative	Negative

 

Shaanxi Hongkang Biological Technology Co., Ltd was founded in 2010, professional committed to the
natural plant active ingredient research, development, production and sales, with own import and export rights.
Widely used in cosmetics, health products, food additives and other industries. Shaanxi Hongkang will
continuously to focus on and serve human health from a global perspective, and create high-quality products
in the field of green health.

After years of continuous development, company has been accumulated rich experience in international trade
and customer resources, established a stable customer base and perfect marketing service network.Company
has perfect quality assurance system, implement strict quality control standards.

The quality management department is equipped with a number of sets of UV, GC,HPLC, GC-MS and other
advanced testing and experimental instruments.Besides, it has a detailed division of labor for the three functions
of process research, quality assurance and quality inspection, which can effectively and comprehensively control
the quality of the production process, conduct comprehensive inspection and analysis on the final product, and
ensure the quality of the product.

Providing users with satisfactory products is our constant pursuit. the company has several plant extraction
production lines in the workshop,And supercritical CO2 extraction,column separation technology, membrane
separation technology, high-efficiencycountercurrent extraction, microwave drying technology, spray drying and
other advanced production equipment, and has formed an annual output of 200 tons of high-purity plant extracts
production capacity, Complete product specifications and stable quality.With the certificate of ISO9001:14001:45001.

Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples. Or if you have special requirement on the goods, we can prepare 
samples according to your requirement and send to you for your confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can 
either pay us the shipping cost or arrange a courier to collect the samples.

Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g. For other low value product, 
our MOQ starts from 100g and 1kg.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.

Q5: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by 
Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation., then you can make 
payment accordingly.

Q6: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to 
customer. In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your 
payment immediately.
 

How to order? 
1. Make sure your quantity need and Leave us message, with your mailed details shown: Including contact name,
    address information, contact phone, etc.
2. We send you a PI (Proforma Invoice) for price and payment detail.
3. Payment by Paypal or Western Union or T/T.
4. We arrange the delivery and update you the tracking number in time.