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Cnidium monnieri Extract Osthole
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White, light yellow, brownish yellow powder
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Osthole 10%, 50%, 90%, 98%
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Osthol, also known as methoxyparsley, parsley methyl ether, is a coumarin compounds, in the umbrella plant
osthol content is high, so called osthol. In 1909, Herzog and Krohn first obtained the compound osthol from
the roots of the umbrella plant europhus. At present, it is widely found in plants, mainly in umbelliferae and
rutaceae, and also in a few compositae and legumes. Commercial cnidium cnidium is mainly extracted from
dried and ripe fruit of cnidium cnidium. Cnidium is mainly distributed in guangxi, jiangsu, anhui, shandong,
hebei, etc. Because of its various biological activities, cnidium is widely used in cosmetics, medicine and
agriculture.
Specifiaction:
Osthol : 1%, 98% by HPLC
Antiarrhythmic effect
Water extract and total coumadin from fructus cnidium have obvious preventive effects on
chloroform induced ventricular fibrillation in mice and calcium chloride induced ventricular fibrillation
in rats. Fructus cnidium and zanthoxylum acetaminophen also have this pharmacological effect and
can improve ventricular electrofibrillation threshold in rabbits. The water extract, total coumarin,
cnidium, and phenols of zanthoxylum had significant inhibitory effects on the flow of sodium ions in
the myocardial cell membrane.
Antihypertensive, inhibition of vascular dilatation
Osthol had a dose-dependent negative inotropic effect on the left atrium of isolated guinea pigs
and a negative frequency effect on the left atrium of isolated guinea pigs. In addition to the polarization
induced by norepinephrine, CaCl2 and high K+, the aorta contraction dose-response curve of rabbits
was shifted to the right and the maximum response was decreased, indicating the role of biosynthetic
compound in relaxing vascular smooth muscle. Fructus cnidium has a certain antihypertensive effect.
Effects on respiratory system
Cnidium monnieri total coumarin with relaxation by drugs (histamine and acetylcholine) caused by
bronchial spasms and diastole bronchus role directly, this function can be B - adrenaline receptor
blockers block by propranolol, mice after total coumarin cnidium monnieri, obviously increase the
amount of phenol red drain in the body, shows strong expectoranting action.
Anti-inflammatory effects
Cnidium cnidium and phenolic zanthoxylum could inhibit the ear shell swelling of mice caused by
xylene and the increase of capillary permeability in abdominal cavity caused by acetic acid. Osthol and
acetonol had significant inhibitory effects on foot swelling in rats and rats with bilateral adrenal resection.
Osthol could also reduce the PGE content in the inflammatory tissues of the swollen part of the foot in
rats, but osthol did not affect the PGE content in the inflammatory tissues of the swollen part of the foot in rats.
Effects on the nervous system
The total coumarin of cnidium cnidium has an inhibitory effect on central nervous system. Osthol can
significantly enhance the hypnotic effect of pentobarbital sodium on subthreshold hypnotic dose in mice,
and this hypnotic effect is dose-related. Cnidium cnidium can promote the learning and memory of mice,
and significantly improve the memory acquisition, consolidation and direction discrimination of mice.
Anti - mutagenesis, anti - cancer effect
Cnidium, parsley b, bergamot lactone, isorhein, zanthoxylum acetaminophen and zanthoxylum toxin
have high activity in inhibiting the mutagenesis of aflatoxin B1. Water extract of cnidium could inhibit S130
sarcoma, prolong survival days and inhibit tumor growth.
Package:1kg/aluminum foil bag;25Kgs in fiber-drums with two-plastic bags inside
Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum
Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum
Storage:Stored in dry and cool place,keep away from strong light and heat.
Shelf Life:Two years when properly stored.
Delivery Time:Around 3-5 workdays after your payment.
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